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Historically, microscopy has played a major role.
Live video microscopy has played a special role in studies on egress.
The present review will focus on the role microscopy has played in our understanding of the phagocyte NADPH oxidase.
Lens-based (far-field) fluorescence microscopy has played a key role in the life sciences, but for most of the time the resolution has been limited to about Δ r= λ/(2ΝΑ)>200 nm, with λ denoting the wavelength of light and NA the numerical aperture of the lens.
However, given the enormous breadth of the cardiovascular disease field, by way of example, we will now restrict our focus to studies we have been involved with to highlight the role microscopy has played in investigating atherosclerotic lesion formation and the response of the myocardium to an ischemic event.
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Electron microscopy (EM) has played a major role in establishing dynein's complex architecture and its nucleotide-dependent conformational changes.
Cryo-electron microscopy (cryo-EM) has played a major role in elucidating several aspects of MT-bound kinesin mechanochemistry (Sosa and Milligan, 1996; Sosa et al., 1997; Rice et al., 1999; Skiniotis et al., 2003; Hirose et al., 2006; Kikkawa and Hirokawa, 2006; Sindelar and Downing, 2007, 2010; Goulet et al., 2012, 2014).
"He has played well.
As mentioned above, fluorescent proteins have played a key role in microscopy studies providing insight on cell structure.
I've played Cruella.
Some might have played on.
Related(15)
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