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Dominic Tildesley, president of the Royal Society of Chemistry, said: "Betzig, Hell and Moerner's work to improve the resolution of traditional light microscopy has enabled scientists to bring their understanding of physiological process into much sharper focus – right down to the molecular level.

The recent advent of intravital microscopy has enabled the real-time visualization of the complex interplay between viruses and the ensuing adaptive immune response in living organisms.

In the past 15 years, the advent of aberration correction technology in electron microscopy has enabled materials analysis on the atomic scale.

This new application of confocal microscopy has enabled measurements of the dynamics of nylon membrane precipitation with sufficient time and depth resolution to permit quantitative testing of models of the precipitation process.

For example, using fluorescent labels, time-lapse microscopy has enabled researchers to examine dendritic arborisation in vivo.

Motivation: Recently, confocal light sheet microscopy has enabled high-throughput acquisition of whole mouse brain 3D images at the micron scale resolution.

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Advances in electron microscopy have enabled visual images of individual molecules and atoms to be produced.

Recent developments in single-molecule localization microscopy have enabled the dynamic visualization of individual tagged proteins inside living cells.

Recent advances in fluorescence microscopy have enabled high-resolution imaging and tracking of single proteins and biomolecules in cells.

Recent advances in Raman microscopy have enabled a study of the changes in internal strain associated with crrep and recovery.

Recent advances in in vivo optical microscopy have enabled us to observe and interrogate cells and their processes with high spatial resolution in real time and in their natural environment deep in the brain tissue.

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