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In addition to the acid effects of carbon dioxide, a highly acidic microenvironment is created by the roots of living plants.
Importantly, the microenvironment is created by the cells themselves as a consequence of their motility that creates random cell interactions.
In the liver parenchyma, tumor cells establish a crosstalk with the stroma, and like this, a special microenvironment is created.
Together with other structural constituents, proteases and their inhibitors, as well as associated molecules, an ECM microenvironment is created, in which intimate contact of HPCs with supporting cells, such as stellate cells, myofibroblasts and macrophages, occurs [ 2, 3, 6].
In these cases, the nerve will grow and regenerate from the proximal stump towards the distal nerve stump, while the ingrowth of fibrous tissue and neuroma formation are prevented by the tube-guide and simultaneously, a favorable microenvironment is created for the Wallerian degeneration and regeneration process during the healing period [ 6].
Mainly due to the release of mediators, such as retinoic acid, TGF-β and thymic stromal lymphopoietin by the enterocytes and/or immune cells, a unique and predominantly tolerogenic microenvironment is created in the submucosa, setting the stage for maintenance of immune homeostasis.
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The stiffening of the microenvironment was created by using a peptide linker with additional tyrosine residues, which were susceptible to tyrosinase-mediated crosslinking.
In this study, a novel biomimetic bone microenvironment was created by integrating hydroxyapatite (HA) and native bioactive factors deposited by osteogenic induction of human bone marrow mesenchymal stem cells (MSCs) within a cytocompatible chitosan hydrogel.
Consequently, S. mutans growing in the presence of sucrose and gradual availability of starch hydrolysates may display enhanced aciduricity/growth efficiency as the redox potential and oxygen levels fall, and low pH microenvironments are created over the course of biofilm maturation [44].
The relationship between the stem cells and the cancer cells may depend on the microenvironment which is created by these two kinds of cells and others [ 28- 31].
They form elaborate and functional networks with other neurons and also rely on a sophisticated microenvironment that is created by the interactions with other neural and non-neural cell types, which provide structural, metabolic and functional support as well as effective communication (Abbott et al, 2006).
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