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Similar to our control experiments (Fig. 1), group mean activity profiles from Bmal1+/+ mice showed that mice were active during the time of prior food availability on the first (601±1005) and second (4104±1941) days of food deprivation (Fig. 2B; FAA from individual mice shown in Fig. 3B).

In contrast, by gradually reducing food availability and by placing food pellets on the bottom of the cage, we found that most Bmal1−/− mice were active and healthy during restricted feeding [39].

In the first stage of the experiment, all the mice were active for the first few minutes after oral infection with the bacterial isolates.

Moreover, the grossly delayed formation of secondary ossification centers and reduced bone mineral accrual in Thra1 PV /+ mice persisted throughout growth when mice were active and gaining weight.

All mice were active and in good general condition when transferred to their home cage 2 3 hours after implantation was completed.

Levels of phosphorylation reached a peak during the dark phase of the daily cycle when mice were active (feeding), and dropped low during the middle of the light part of the daily cycle, when mice slept/rested (fasting), supporting the previously published observations on the regulation of mTORC1 by feeding.

Similar(54)

Although the details of timed gene expression are likely to differ between mice and humans — mice are active at night rather than during the day — it could be that the majority of human genes fall into this category.

Others were given access to running wheels only in the early portion of their waking time (mice are active at night) or in the later stages, the equivalent of the afternoon for us.

The LysM gene in mice is active mostly in monocyte/macrophages and neutrophils [38], [39].

In the social interaction test in the home cage, time spent separated is usually increased when mice are active and decreased when mice are sleeping.

It is intriguing that hypothalamic AMPK activity has a diurnal oscillation that peaks during the dark period when mice are active and eating.

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