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We had previously found that neither the cytokine, interleukin-2, nor the pharmacological agent, indomethacin, both potent stimulators of NK cell numbers/function in younger adult mice, was effective in stimulating NK cells in elderly mice.
Luciano et al. (1995) also reported that the potentiation of the antitumor actions of IFNs administered by intramammary injection to human breast cancer xenografts growing bilaterally in nude mice was effective at the local but not at the systemic level indicating that the drug accumulation in the local area of breast tissue is a critical factor in breast tumor regression.
The administration of Salecan to the constipated mice was effective in increasing the fecal number and fecal weight, which were indications of the laxative character of Salecan.
Analysis was performed to assess whether administration of CpG ODN in 3xTg-AD mice was effective in inducing immunostimulatory response in the absence of any toxicity.
Our findings confirmed that the recombined RBP-J allele was a true null allele and that inhibition of the Notch/RBP-J pathway in the double-mutant mice was effective.
Long-term bromocriptine treatment of adult mice was effective in the control of obesity, pituitary growth, and disturbances in the hormone profile, demonstrating that hyperprolactinemia was the main cause of the hCGβ+ female phenotype.
Similar(53)
Recent works showed that deliveries of 106 to 109 living GMMs into mice were effective for vaccination34,35 or oncolytic therapies36.
Previously published immunocytochemical data have shown that the av3J/av3J and v2J/v2J mice are effective nulls for Pcdh15 and Cdh23 respectively [11], [25].
In fact NC(4 h), but not NC 7 d) or NC infused to sham-operated mice, are effective in protecting from ischemic injury and induce a more marked microglia/macrophage activation.
Testing these concepts in mice is effective because large cohort sizes can be used using low cell numbers to generate a minimal cancer burden to reflect the tumor recurrence rates seen in patients.
Finally, Hr expression did not attenuate apoptosis in mouse embryonic fibroblasts from p53 knockout mice but was effective in mouse embryonic fibroblasts from wild type mice.
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Justyna Jupowicz-Kozak
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