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Histopathological examination indicated that the STZ-lesioned pancreas tissue in PR-administrated mice was effectively alleviated.
Evidence for this latter point has recently been provided using an experimental atherogenesis model, where the development of aortic lipid lesions in apo-E-/ mice was effectively prevented and even reversed by intravenous injections of liposomal formulations of synthetic peptides corresponding to SAA's two functional domains [36].
The growth of murine MC-GP tumors, which show high endogenous COX-2 expression, in immunocompetent mice was effectively suppressed by treatment with a selective COX-2 inhibitor, celecoxib.
Primary tumour growth of PyMT mice was effectively curbed with a high dosage of cisplatin treatment (2.5 mg/kg, ip. twice a week), whereas PyMT/endotrophin mice were resistant to the effects of cisplatin treatment (Fig 3A).
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Untreated, the mice were effectively blind in dim light.
After a fortnight the number of seizures dropped dramatically and the mice were "effectively cured" within a month.
Whereas before, lab mice were effectively party favours, traded between labs within the small, tight-knit experimental community, now, you had to pay a hefty charge per unit to DuPont.
Since Nr2e3 is not expressed in Nrl-/ [13], these mice are effectively Crx-/- Nrl-/- Nr2e3-/-.
It remains unclear how the human T cells generated in NOD-scid IL2rγnull mice are effectively educated.
LK2 tumours in nude mice were effectively treated with 0.1%% ingenol mebutate given daily for 3 days [ 4].
These results indicate that degeneration of AHCs and the resulting motor dysfunction in AR2 mice were effectively prevented by AAV9-mediated delivery of ADAR2.
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