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In mice, these effects were limited to the visual cortex.
In mice, these effects of IMQ produce red, scaly skin similar to human psoriasis, and indeed, clinical observations have indicated that IMQ can exacerbate psoriasis in patients [17] [20].
However, in TAAR1-KO mice these effects of 3-MT were reduced (Figure 3C,D,E) with the lowest dose (9 µg) being completely inactive in the mutants (Figure 3A,B).
In mice, these effects have been observed after a single dose of < 1 10 mg/kg.
Further, mice these effects are exacerbated in mice fed a high fat diet, supporting the notion that rapamycin treatment may drive the onset of type 2 diabetes.
In this study, although PCB-77 impaired glucose and insulin tolerance in lean mice, these effects were lost when mice were fed a HF diet.
Similar(54)
NCX 4016 significantly reduced the total number of atherosclerotic lesions and the number of initial macrophage-rich lesions in carotid arteries of unirradiated mice, but these effects were not maintained in irradiated mice.
Weight loss improved glucose and insulin tolerance and reduced fat levels of TNF-α in all the mice, but these effects were significantly weaker in exposed mice than in unexposed animals.
Two week HFD increased plasma leptin levels, adipose tissue macrophages and cytokines, and adipocyte size in WT mice but these effects were absent or blunted in OPN KO mice.
LPS caused a significant reduction in food intake and body weight in DIO mice at 8 hours compared with vehicle-treated DIO mice, and these effects were still observed 3 (body weight) and 4 (food intake) days after injection (Fig. 1A,C).
ATP (1 mM) and the P2X7R agonist BzATP (100 μM) significantly increased p38 MAPK phosphorylation in WT mice, and these effects were absent in the hippocampal slices of P2X7R−/− mice.
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