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We found that when implanted into mice, these cells secreted high plasma levels of sIGFIR and inhibited experimental hepatic metastases of colon and lung carcinoma cells.
Following a few weeks (at E33 in humans and E10 in mice) these cells become localized to the subventricular zone (SVZ), where they become radial glia cells and begin to divide asymmetrically, with one daughter cell maintaining NSC characteristics and the other differentiating into a neuronal fate.
After being transplanted to mice, these cells were able to generate fully functioning human corneas.
In humans and mice, these cells constitutively express CD25 and have suppressive effects on T and B cells [8], [13].
Following transplantation into the eye of immune-compromised retinal degenerative mice these cells proceeded to form teratomas containing tissue comprising all three germ layers.
In severely wasting mice, these cells became especially abundant (Figure 6 F) and co-expressed low levels of F4-80, i.e., were Gr-1dimF4-80dim Gr-1dimF4-80dim Gr-1dimF4-80dim
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Inoculated in nude mice, these cell lines initiated tumour growth [ 48].
Together with the transgenic mice, these cell lines now provide a useful experimental system for gastric cancer.
In mouse, these cells have an embryonic origin in Rathke's pouch undifferentiated precursors (i.e. HESX1 and SOX2 expressing cells) [ 18].
They are rare but present in the cecum and proximal colon of humans, whereas, in the mouse, these cells are entirely absent in the colonic mucosa and uniquely found in the cecum.
Although p63 is expressed in TE progenitor cells of FoxN1null mice, these p63+ cells cannot develop into mature TECs as nude (FoxN1null) mice do not have mature TECs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com