Sentence examples for mice recapitulate many from inspiring English sources

TSP-1 has been shown to activate latent TGFβ1 in vitro, and TSP-1−/− mice recapitulate many of the same phenotypes that TGFβ1−/− mice display [33].

αB-R120G heterozygous and homozygous mutant mice recapitulate many of the pathologic features observed in DRM patients, including myopathy, desmin aggregates, and mitochondrial pathology [52].

10.7554/eLife.02676.007 Figure 5. R306C mice recapitulate many RTT phenotypes.

The majority of these mice recapitulate many characteristics of ALS, including progressive motor deficits, hindlimb paralysis, motor neuron degeneration and early death (6, 12, 13).

Our mice recapitulate many aspects of the clinical phenotype and pathological features of TDP-43-linked ALS with slow and rapidly progressive motor phenotypes.

Remarkably both early and late-onset mice recapitulate many of the pathological features of TDP-43 proteinopathy that typifies ALS providing a powerful model to explore disease mechanisms and conduct preclinical trials.

Administration of recombinant HMGB1 to mice recapitulates many clinical signs of sepsis, including fever [16], [17], derangement of intestinal barrier function [18], and tissue injury [19], [20].

Altogether, the CLL developed by these mice recapitulates many aspects of refractory CLL disease in humans, and as such, this CLL mouse model might be suitable as preclinical model for testing new drugs for CLL.

Long-term exposure to HDM in mice recapitulates many features of human asthma, including airway hyperresponsiveness, airway wall remodeling and chronic airway inflammation which transitions from a predominantly eosinophilic to neutrophilic inflammatory profile as the disease progresses [23], [31].

We report here that astrocytic elevation of MAO-B in adult mice recapitulates many of the pathological hallmarks associated with human PD and that these effects can be prevented by treatment with the selective MAO-B inhibitor deprenyl or the antioxidant EUK189.

The R306C mice, though displaying milder phenotypes than Mecp2 null mice, recapitulated many phenotypes seen in RTT patients, such as increased anxiety, motor dysfunction, and learning and memory deficits (Hagberg et al., 1983; Chahrour and Zoghbi, 2007).