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As a model for human trisomy 21, these mice display many attractive features, including performance deficits in different behavioral tasks, alterations in synaptic plasticity and adult neurogenesis, motor dysfunction, and age-dependent cholinergic neurodegeneration.
PPT2 knock-out mice display many of the same INCL phenotype and pathology including spasticity and autofluorescence accumulation in the brain [32].
Taken together, these results suggest that these mice display many behavioral alterations considered analogous to several aspects of schizophrenia.
YapKIAlb-Cre mice display many features described in other in vivo models of Yap induction, including increased proliferation, dedifferentiation, and activation of TEAD target genes.
They report that homozygous Rab18 mice display many of the major ocular and neurological abnormalities that are associated with Warburg Micro syndrome, including congenital nuclear cataracts, atonic (constricted) pupils and progressive limb weakness.
Although we did not perform direct measurements of fatty acid oxidation, this is in line with a previous study showing that mitochondria of middle-aged mice display many electron transport chain defects and decreased complex I and IV activities [ 41].
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S. japonicum-infected µMT mice displayed many fewer hepatic surface nodes than control C57BL/6 mice at five weeks post-infection (data not shown).
This mouse displays many of the phenotypic features normally associated with endothelial dysfunction.
Cell lines derived from the mouse tumors display many of the molecular characteristics of human NB [22] although the tumors rarely exhibit loss of the mouse gene region that is syntenic with chromosome 1p36 or metastasize to distant organs such as bone marrow [21], [23].
Mouse models of RTT display many of the clinical features seen in RTT, and both male (Mecp2 Null/Y) and female (Mecp2 Null/+) mice recapitulate the LQT observed in people with RTT (McCauley et al., 2011).
Transgenic C22 mice, a model of CMT1A, display many features of the human disease, including slowed nerve conduction velocity and demyelination of peripheral nerves.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com