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PD-1−/− mice develop many kinds of autoimmune diseases [ 14– 16].
Consistent with this possibility, neonatally androgenized female mice develop many of the features of metabolic syndrome [ 31, 65, 66].
When subjected to the two-stage DMBA/TPA protocol, the BK5.EP4 mice develop many more tumors than wild-type mice.
These mice develop many of the brain malformations associated with severe forms of dystroglycanopathy, including disruption of the basement membrane and aberrant neuronal migration in the cerebrum and cerebellum [ 4, 40, 41].
For example, diabetic mice develop many similar features to AD mice [ 146] and a mouse model of chronic heart failure shows alterations in the metabolism of cerebral Aβ and cognitive impairments [ 147].
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In contrast to what we observed at five weeks post-infection, OBF-1-null mice developed many hepatic surface nodes by week eight of infection.
Heterozygous PTEN-null mice (PTEN+/− mice) spontaneously develop many different tumours [ 8– 10].
Unlike p53, few, if any, p21 mutations have been found in human tumors and p21 knockout mice do not develop many more spontaneous malignancies than their wildtype littermates [ 5].
Background Cre recombinase has been used to develop many mouse models of primary cancer through enabling deletion of tumor suppressors and activation of oncogenes in somatic tissues of mice in a spatially and temporally restricted manner.
Our hypothesis for breast cancer is supported by what happens in the Lewis lung animal model [ 3], in which 100% of mice injected with this tumor develop many lung micrometastases that do not vascularize and grow while the primary tumor is intact.
Haldipur et al. found that mouse embryos specifically missing this receptor develop many of the abnormalities seen in Foxc1-deficient mice and further, when SDF1-alpha was provided back into Foxc1-deficient cerebella, the defects were rescued.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com