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Exact(6)
Bevacizumab has a half life in mice of approximately two weeks [22].
The most significant finding made in the present study was that the HB-EGF KO mice had a significantly decreased spine density on the primary apical dendrites of the layer III pyramidal neurons of the prefrontal cortex (vs. control mice) of approximately 40%.
We could demonstrate that 5% DSS in drinking water resulted in a weight reduction of control-treated Foxp3-GFP-DTR mice and DTx-treated Foxp3-GFP mice of approximately 20% on day 7 after the beginning of DSS administration.
Male mice of approximately 8 12 weeks old were intraperitoneally injected with 20 ng LPS diluted in NaCl 0.9% or with an equivalent volume of NaCl and fasted for 16 hr.
For the BLM-induced pulmonary fibrosis model, mice of approximately 8 weeks old (at least 5 mice per group) were intratracheally intubated and dosed with BLM (1.2 U/kg) at day 0. Mice were killed on 3, 6, and 9 weeks after BLM intubation, and bronchoalveolar lavage (BAL) fluids obtained by lavaging lungs with 1 mL PBS [ 16].
We generated an antimouse GM-CSFR neutralising antibody CAM-30033) (see online supplementary methods) and determined its pharmacokinetic profile in a single ascending dose study in female 8-week-old CD1 ICR) mice of approximately 20 22 g (see online supplementary table S1).
Similar(54)
Considering that the regular daily consumption of water per mice is 4 ml and the average weight is 20 g this concentration ensured the consumption per mouse of approximately 0.3 μg/g/day dexamethasone (ethanol consumption was lower than 5 μl/mouse/day).
In control mice, levels of approximately one half of the proteins differ significantly between females and males in at least one brain region; in the hippocampus alone, levels of 40%% of the proteins are significantly higher in females.
Based on this mutation rate, a size of the mouse genome of approximately 2.5×103 Mbp and assuming that approximately 1.5% of the genome encodes a protein, we anticipate that each G1 founder contains about 25 mutations that affect protein sequence.
Similarly, ten mouse islets of approximately the same size were incubated in duplicate at 6.5 and 22 mmol/l glucose for 2 h at 37°C.
These bands had an equal intensity and were comparable with the control mouse band of approximately 90 kDa (see Figure 5).
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