Thus, for example, in a pig of 25 kg with a liver of approximately 490 g in which 4,500 MBq Ho is administered, the absorbed organ dose is 15.87 × 10−3 J MBq−1 × 4,500 MBq/0.490 kg = 146 Gy.
In a complex architecture of nested, zonated lobules, the liver consists of approximately 80%% hepatocytes and 20%% non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage.
Diluted liver paste consisting of approximately 4 1 liver:planarian water and 20 µl red food coloring was mixed and 25 µl was pipetted into the petri dish.
Expression of Arntl and Npas2 were significantly (p<0.05) (Fig. 5B) increased from G20 to P1 in the liver of control (approximately 10-fold and 16-fold, respectively) and HG (2-fold and 4.4-fold, respectively) dams.
After removal of the liver, a section of approximately 4 mm was fixed in PAF and embedded in paraffin.
At the end of the experiment, liver tissue samples of approximately 15 g were taken from the living animal for isolation of mitochondria.
A liver tissue sample of approximately 0.5 g was digested in a solution consisting of a mixture of HNO3-HCLO4 for 2 days at 130°C.
LY411,575 was found to prevent Plasmodium's normal development in the liver, with an IC50 of approximately 80 nM, without affecting hepatocyte invasion by the parasite.
While the change in blood AUC is modest (13%) (Table 4), the impact of using measured physiological values is potentially high when simulating concentration-time curves within certain organs, with changes in liver and intestine AUCs of approximately 50%.
Histopathological examination of a range of tissues (brain, skin, stomach, aorta, muscle, liver, kidney and lung) of approximately 500-day-old male mice did not reveal any substantial differences between WT and p110αD933A/WT animals.
