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Except for the gene expression changes (Fig. 5 and Fig. 6), the degree to which the circadian rhythm is disrupted in these AMPK-deficient mice is rather modest.

Collectively, these data show that the impaired thymic generation of Treg cells in IκBα-SR Tg mice is rather due to a Treg cell-intrinsic defect than an extrinsic one, because it cannot be compensated despite the presence of wild-type derived T lymphocytes and soluble factors.

However, the regulation of PI3K activation in p85 α-deficient mice is rather complex.

These data suggested that the increased osteoclastogenesis observed in MLII mice is rather caused by the strong expression of Il-6 than by a change in the ratio of osteoblast-derived Rankl and Opg.

Rapid MDBs formation in primed mice is rather non-specific, since it can be triggered by a variety of stress conditions including colchicine (but not by lumicolchicine), bile acids, bile duct ligation, several other toxins, and proteasome inhibitors which were unable to induce MDBs in the naïve animal (Zatloukal et al. 2007, and references therein).

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Hq mice were rather hypoglycemic compared to wt.

These findings show that, contrary to our initial hypothesis, aged MCK-UCP1 mice are still able to efficiently respond to NMJ-inducing stimulatory nerve factors and suggest that the NMJ defects of these mice are rather presynaptic.

The increase in adiponectin levels in Nscl-2 mice was rather unexpected since adiponectin levels are usually inversely correlated to percent body fat resulting in the reduction of adiponectin concentrations in obese animals (see [36] for a review).

Such models, especially models using immune-competent mice, are rather scarce.

However, the effect of royal jelly on the maximal lifespan of mice was rather disappointing [ 35].

Furthermore, genetically modified mice are rather costly and may impose a substantial financial constraint to a research as well as limit the number of samples.

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