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Comparison of effects of metformin on various biomarkers of aging in different strains of mice shows rather notable similarity in observed patterns (Table 7).
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Accordingly, reduced recruitment of endothelial progenitor cells (EPC) from the bone marrow has been reported in neonatal mice in response to hyperoxia while adult mice showed rather increased EPC levels [59].
Female TG mice showed rather stable glucose levels until week 60 of the diet (Fig. 5B).
Loss-of-function mutations of GlyR α or β-subunits in mice show rather severe neuromotor phenotypes.
Perhaps surprisingly, we found that GASP-1 KO mice show lower (rather than higher) baseline levels of D2Rs.
An analysis of Casp-1−/− mice show that rather than diminished IL-1β, they had increased lung IL-1β in their lungs compared to wild type as measured by ELISA (Figure 5D).
This was best observed in the novel object detection task, wherein the CGG KI mice displayed no deficits whatsoever, whereas the Fmr1 KO mice showed a rather profound inability to perform the task.
However, other studies on obese mice showed increased rather than decreased mitochondria density, respiration, enzyme, activity and fatty acid oxidation (Hoeks et al. 2011); expansion of muscle adipose depots in obese humans did not associate with MT dysfunction (Machado et al. 2012); and in obese rats, MT dysfunction was found to be a late event (Chanséaume et al. 2007).
Two open reading frames in the mouse genome show rather low similarity to the CDO sequence but have the key cupin metal binding motif rather well conserved.
A good script shows rather than tells.
Surprisingly, cells from these mice showed evidence of reduced, rather than increased auto-modification of PARP-1, possibly due to abnormal interaction between the truncated PARG and PARP-1 or XRCC1 [20], [35], [35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com