Sentence examples for mice harboring human from inspiring English sources

We demonstrate that such vectors induce gene transfer, both in vitro and in mice harboring human tumor xenografts, only through contact with target cells expressing MMPs that cleave the substrate introduced into the recombinant HA.

Thus, a CRAd driven by the SPARC promoter was therapeutically effective leading to the cure of more than 50% of mice harboring human melanomas composed of malignant cells alone.

They observed that lanatoside C, alone or in combination with TRAIL, reduced tumor growth in nude mice harboring human U87 glioblastoma cells.

In the transgenic mice harboring human osteocalcin enhancer/promoter luciferase reporter gene, strong osteogenic activity was observed by 1 α,25(OH)2D3 administration, compared with 1 α,25(OH)2D2, as well as previtamins D2 and D3.

Based on the observations of Gupta and colleagues [ 29] and on the plasma levels of digoxin in cardiac patients, we discussed the fact that the potent anticancer effects induced by digoxin in mice harboring human cancer cells [ 17] were not relevant to the treatment of human cancer and these anticancer effects were probably due to interspecies differences in sensitivity [ 25].

Mice harboring human microbiota had low levels of mucosal CD4+ and CD8+ T cells, few dendritic cells and reduced antimicrobial peptide expression.

3xTg-AD mice harbor human mutant PS1 (PS1M146V) along with human mutant APP (APPswe) and tau (tau P301L) protein.

Transgenic mice harboring a human TSPY gene on their autosome(s) are difficult to maintain as transgenic mouse lines, potentially caused by its inappropriate expression and disruptive effects on the reproductive system or embryonic development of the host animals [ 42].

Consistently, this association pattern, with a large number of GFAP-positive astrocytes surrounded amyloid plaques, has also been reported in TgCRND8 mice harboring the human APP gene with the Indiana and Swedish mutations [ 45] and in APPswe/PS1dE9 mouse brains [ 59].

In combination with antibodies harboring human or mouse Fc domains α-Fc-ETA′ inhibited proliferation of antigen-expressing tumor cells.

The advent of transgenic immune-deficient mice has made it possible to generate chimeric animals harboring human tissues and cells, including hepatocytes.