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Not unexpectedly, the mice receiving human GCase developed antibodies to this antigen in almost all circumstances.
In contrast, we found that ischemia-induced neovascularization was not improved in mice receiving human aortic endothelial cells [4].
Mouse mortality was significantly higher (p<0.01) in mice receiving human neutrophils containing phagocytosed K1 than those receiving human neutrophils containing phagocytosed K6 (Fig. 4A).
There do not appear to be any particular adverse effects of the administered enzyme secondary to antibody production, although there were IgE-mediated reactions in these mice receiving human GCases leading to death.
Recent attempts to prove the pathogenic relevance of NMO-IgG have focused on rats as recipients of purified IgG fractions from NMO-patients because rat but not mouse complement binds to purified human NMO-IgG [23] and thus, NMO-IgG dependent CNS damage can easier be shown in recipient rats than in mice receiving human serum IgG.
There are at least 3 possible explanations for these findings: in mice receiving human myeloma marrow cells they might be accounted for by the persistence and replication of these cells in an immunologically deficient host.
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All mice received human care.
Nude mice received human EPCs treated with IFR in high glucose medium showed a significant improvement in blood flow recovery in ischemic limb compared to those without IFR therapy.
Dazzi reported that multiple but not single infusions of MSCs prevent the generation of GvHD effectors in a NOD SCID (nonobese diabetic, severe combined immunodeficient) mouse model receiving human donor lymphocytes.
Compatible with the result of blood flow measurement, mouse and/or human CD31 positive capillary density markedly increased in mice that received human VPC-derived EC+MC (1856.8±57.0/mm2) (P<0.0001, compared to the control group (1318.6±73.0//mm2)), and also to other groups.
The average number of collagen-specific cytokine-producing T cells per million spleen cells at four weeks post-implantation in mice that received human osteochondral grafts is shown in Figure 3.
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