Transgenic mice expressing human VAP-1 on endothelium showed a higher signal in chemically induced ear inflammation, in comparison to the control site, and to VAP-1 deficient knockout mice.
To readdress this question by rigorous quantitative methods, we analyzed transgenic mice expressing human β-CTF with the I45F mutation (SPA4CT) under control of the prion protein promoter by stereological techniques.
In order to more specifically investigate the relationship between HO-1 and ICH outcome, mice expressing human HO-1 driven by the glial fibrillary acidic protein (GFAP) promoter (GFAP·HMOX1 mice) were tested in a model of in situ parenchymal hemorrhage.
DR2bxPSA F1 male mice expressing human PSA and HLA-DRB1*1501 transgenes were vaccinated with virus-like particle vector encoding PSA (VLPV PSA) followed by the challenge with Transgenic Adenocarcinoma of Mouse Prostate cells engineered to express PSA (TRAMP PSA).
Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP91 110 induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS).
We generated mice expressing human HSP70 (HSPA1A) under the control of Thy1 regulatory sequences (Figure 1A).
Animal studies have revealed that transgenic mice expressing human APOE4 had more phosphorylated tau proteins [26].
APP23 mice expressing human APP751 cDNA containing the Swedish double mutation (K651M and N652L) were used for this study [8].
For example, hyperbranching occurs in the mammary epithelia of transgenic mice expressing human heparanase, a degradative enzyme secreted by cells [28].
Here, we describe the development and characterization of transgenic mice expressing human LRRK2 bearing the familial PD mutations, R1441C and G2019S.
However, mice expressing human α-synuclein (wild type and A53T) on the mouse α-synuclein null background show significant sensitivity to MPTP (Fig. 3B-E).
