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Histopathology and serum biochemistry profile in mice further indicated the suitability of the proposed formulation.
In vivo injection into NSG mice further indicated that the CB CD34+CD38−CD110+ population is highly enriched in HSCs compared with both CD34+CD38−CD110− and CD34+CD38− populations.
The lethality observed in Parp1−/−/Parp2−/− mice further indicated that PARP3 cannot compensate for the absence of PARP1 and PARP2 during mouse development.
Naris occlusion experiments and analysis of CNG channel-deficient mice further indicated that RAR-regulated CNG channel levels influenced the intrinsic neuronal activity required for cell survival in the absence of odor stimulation.
Furthermore, the spontaneous rectal prolapse and colitis that developed in the CD4cre:PP4f/f:Foxp3-GFP+ mice further indicated an immune regulatory function of PP4 for maintaining the immunological balance in the gut.
Similar(55)
The absence of MMOs in the immediate firing motoneurons of mSOD1 mice further indicates that these motoneurons are more excitable than in WT mice.
We also observed that expression of the growth suppressor Cadm1 was increased in islets of βAgo2KO mice, further indicating that the regulation of several targets of miR-375 was dependent on Ago2 (Poy et al., 2009).
Mice deficiency of IFN- γ signalling developing spontaneous tumours at a higher frequency than normal mice further indicates that IFN- γ is involved in immune response to tumours (Kaplan et al, 1998).
Wang et al [ 31] observed that successionary cheek tooth buds, normally absent or very small in wild-type mice, were much more commonly observed in Runx2 mutant mice, further indicating that this locus may contribute to the morphogenetic pathway of the post-primary generation of teeth.
Significantly lower ALT and AST levels were noted in TRAF1-deficient mice than that in WT mice, which further indicated that these mice experience less liver damage following I/R injury.
Characterization of tissue-specific Met knockout mice has further indicated that the HGF Met system modulates immune cell functions and also plays an inhibitory role in the progression of chronic inflammation and fibrosis.
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