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Similar to our observations in C57Bl6 mice, RWE challenge in Balb/c FcγRIIb KO mice further increased total cells (2.3-fold increase), eosinophils (5.2-fold increase) and lymphocytes (2-fold increase) in BAL fluid as compared to WT mice (Figure 2A, 2B and 2C).

Vaccinated mice had higher serum IFN-γ and IL-6 than the PBS administered mice (P = 0.0029) The serum IL-6 and IFN-γ levels of vaccinated mice further increased upon challenge while remaining lower than that of unvaccinated challenged mice (Figure 7A & B).

Interestingly, deletion of CAR in both control and HRN mice further increased Cyp3a11 mRNA levels.

Passively transferring mSOD1 Tregs into mSOD1/RAG2−/− mice further increased the expression of Ym1 compared with mSOD1/RAG2−/− mice receiving mSOD1 CD4+ T lymphocytes.

At 20 weeks of age, the passive transfer of mSOD1 CD4+/CD25+ T lymphocytes into mSOD1/RAG2−/− mice further increased FoxP3 messenger RNA levels compared with mSOD1/RAG2−/− mice receiving mSOD1 CD4+ T lymphocytes (Fig. 4D).

The passive transfer of mSOD1 CD4+/CD25+ T lymphocytes into mSOD1/RAG2−/− mice further increased IL-4 messenger RNA levels compared with mSOD1/RAG2−/− mice receiving mSOD1 CD4+ T lymphocytes.

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Additionally, studies have demonstrated that CCR5 deficiency exacerbated T-cell-mediated hepatitis in mice, further increasing concerns that hepatotoxicity may be a class effect of CCR5 antagonists [31].

However, while plasma renin in WT RAS mice returned to baseline levels after 4 weeks, plasma renin in db RAS mice was further increased at 4 weeks before going back to baseline levels at 6 weeks.

Moreover, IL-23 production was high in psoriatic mice and further increased in the absence of LCs.

Scl-AbI treatment completely prevented this BMD loss in CIA mice and further increased their mean BMD above healthy control level by the end of the experiment.

At the age of 12 months the number of CFU-GM in the CD137−/− mice had further increased from 133±9 to 198±44 per 10 cells.

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