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Apart from aggrecanases, studies in immune models in various FcgR knockout mice further identified that FcgRI is pivotal in driving IC-mediated cell activation, metallo-proteinase activation and concomitant cartilage erosion [ 77- 79].
Significance analysis of microarrays (SAM) (36), with the incorporation of array data from age P71 mice, further identified the increase in Ccl3 expression as significant (q-value = 0) and among the top 18 significantly elevated genes listed, with a false discovery rate of 5.18% (Supplementary Material, Fig. S1).
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Using available microarray data from Nr3c1-KO mice, we further identified 52 genes that are under-expressed in both Nfib and Nr3c1 knockouts, an overlap which is 13.1 times larger than what would be expected by chance.
Pathologists blinded for mouse genotypes further identified the presence of cysts and MCA in all Pdx1-Cre;Vhl f/f mice lacking pVHL in the pancreas (Figure 4A, panel c and f).
The time course of the aberrant miRNA expression was further identified in mouse hearts at 7, 14, and 21 days after aortic banding.
NCD4hi and NCD4lo subsets were further identified as described for mouse cells.
We further identified that the adult iPS-mice exhibited 100% germline transmission (Fig. 1H).
As ESLs are composed of a scaffold protein or lipid decorated by the tetrasaccride sLex, we further identified a lack of sLex in mouse PCa cells.
GUDCA was further identified as an intestinal FXR antagonist that improved various metabolic endpoints in mice with established obesity.
In addition, detailed analysis further identified Arnt2 as another protein sequestered by mutant Nhtt in the model mouse brain.
We further identified 13 experiments in which microarrays were used to evaluate the effects of CR in mice (left margin).
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