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Body weights of G93A mice gradually increased until 11 weeks of age and then stabilized for 2 weeks (12 13 weeks of age).
However, after day 21, the weight of transgenic mice gradually increased and reached the wild-type weight by day 49.
The number of genes that showed significant expression changes in CBA/J mice gradually increased during infection.
In radiation-treated mice, tumor growth was significantly suppressed compared with the control group, but the tumor volume in these mice gradually increased with time.
The body weights of all mice gradually increased and no significant differences were observed among the groups at any given time point.
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As shown in Figure 1B, body weight of AST treated EAE mice was gradually increased after MOG immunization.
As seen, the body weights of all the mice groups gradually increased indicating that none of the formulations were toxic to the animals.
The nuclear hnRNP A3 protein level in the mouse liver gradually increased with age, while its mRNA level stayed age-stable.
Interestingly, the expression of the miR-23-27-24 clusthes in the mouse cortex gradually increased in a manner that was inversely correlated with the pattern of Apaf-1 expression.
In a good agreement with the restoration of dystrophin levels, two weeks after injection the levels of the MYOM3 fragments in treated mdx mice substantially decreased (without reaching the level in the control mice) and then gradually increased over time (Fig. 7C).
While untreated mice and BU-pretreated mice displayed less than 0.2% chimerism, radiation-treated mice displayed gradually increasing levels of chimerism up to 80% in lethally irradiated (900 RAD) mice (Fig. 2B).
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