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The role of inflammasomes in MDSC recruitment and immunosuppression is further supported by a study reporting that tumors derived from Nlrp3−/− mice exhibit less infiltrating MDSC than those from WT mice (van Deventer et al., 2010).
This is demonstrated clearly in the concurrent choice test where both groups consumed the same amount of total food but the sucrose-exposed mice consumed less sucrose— available, but associated with a cost— showing that the sucrose-exposed mice exhibit less incentive motivation to work for sucrose.
For instance, germ-free mice exhibit less anxiety and fear [ 9]: two factors that potentially might be important driving forces of human religiosity.
Our results confirmed the important role of MIF in MMP-2 production, because MIF gene-deficient mice exhibit less joint MMP-2 than wild-type mice.
Meprin α-knockout mice exhibit less renal damage compared with wild-type mice, and meprin β-deficient mice show lower levels of the inflammatory marker IL-6 and decreased leucocyte infiltration after renal injury [ 85, 89].
Furthermore, NO inhibits GAG and collagen II synthesis in chondrocytes and iNOS knock-out mice exhibit less cartilage degradation in models of OA and RA than their wild-type litter mates [ 24- 26].
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These mice exhibited less freezing behaviour when returned to the same cage than others who received no stimulation.
Despite having a comparable liver steatosis score, IL-6-deficient mice exhibited less lobular inflammation than their wild-type littermates.
In contrast NPY−/− mice exhibited less inflammation with an overall clinical score of 4±0.7 compared to a score of 9±0.5 in DSS-WT mice (p<0.01, Figure 2C).
Immunohistochemical (IHC) analysis of GM2 and GM3 gangliosides in the neocortex of Npc1−/− mice yielded similar results in terms of cholesterol storage, with combination and CD-treated mice exhibiting less ganglioside accumulation than untreated mice (Fig. 2B, C).
Both nNOS−/− and NPY−/−/nNOS−/− mice exhibited less inflammation as evident from histological damage (Figure 7A), less cecum shrinkage (Figure 7B), decreased histological score (Figure 7C) and MPO activity (Figure 7D).
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Justyna Jupowicz-Kozak
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