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In 3 week old females, ovaries of Wt mice contained numerous ova surrounded by deep layers of granulose cells, and numerous primordial follicles were present.

In contrast, the markedly expanded and hypercellular thymic medulla of S1PL−/− mice contained numerous mature lymphocytes as well as vacuolated stromal/epithelial cells, macrophages, and histiocytes (Fig. 4B, lower panel).

In 3 week old males, the seminiferous tubules of Wt mice contained numerous pachytene spermatids and spermatogonia, while in Rpn13−/− mice the seminiferous tubules were lined predominately by hypertrophic Sertoli cells, and most of the identifiable spermatids were early stage and undergoing apoptosis (Figure 6).

In contrast, spleens from wild-type BALB/c mice contained numerous cells secreting IgG3.

At 2.5 months post-infusion, the dorsal and ventral fornix of P301SBE mice contained numerous PG-5-positive 'dot-like' structures (Fig.  4).

Lung capillaries in the mutant mice contained numerous granulocytes, but there was considerably less hemorrhage than in the p210 BCR/ABL1 mice.

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In consistency with the previous observation (Straub et al., 2007), the LSECs in normal mice contain numerous sieve plates with open fenestrae (Fig. 1A).

While human connective tissue mast cells contain the enzymes chymase and tryptase, mice contain numerous related proteases [ 49- 51].

In the Hexb−/−FcRγ+/+ mice, the macrophages contained numerous abnormal nuclear-like electron dense particles, which were not evident in the Hexb+/−FcRγ+/+ thymus (Fig. 4A).

The results showed that while the WT mouse brain (Fig. 2J) and that of their heterozygous littermate (Fig. 2K) contained no detectable GRODs, those from both the Ppt1-KI (Fig. 2L) and the Ppt1 −/− mice (Fig. 2M) contained numerous GRODs.

(A) TEM micrograph of sinusoid in normal mice, which contain numerous sieve plates with open fenestrae.

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