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Consistent with this, 24 month old TDP-43Q331K mice demonstrated numerous small cytoplasmic p62 inclusions (Additional file 1: Figure S4), accompanied by occasional small TDP-43 inclusions in the neuropil (Additional file 1: Figure S3), although there was no evidence of any changes in ubiquitin staining in these animals.
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History has demonstrated numerous times that when the legal terrain is more solid, innovation and competition flourishes.
Repeat paracentesis demonstrated numerous motile trichomonads.
Histological evaluation of skeletal muscles of sgk1 − / − mice demonstrated increased variation of fiber size with numerous small and rounded myofibers (Fig 4A).
Ex vivo, aortae excised from Fkbpl+/+ mice demonstrated ordered sprouting; however, this process appeared to be significantly enhanced in Fkbpl+/neo, and vessel sprouts were highly branched and numerous.
All mice demonstrated full visual capability.
Three mice demonstrated subarachnoidal hemorrhages.
Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental effects which appeared to worsen if offspring exposed in utero nursed from PFOA-exposed dams.
Numerous genetic modelling studies in mice demonstrate that neuregulin 1 signalling is important in the development of normal neuronal connectivity.
The numerous developmental defects we identified in these mice demonstrate an essential role for Esrp-regulated splicing in the development of many organ systems.
Robust myelin production with subsequent recovery of sensorimotor function and spinal cord electrophysiology has been demonstrated in numerous mouse, rat and primate models of SCI [1], [39], [40], [41], [52].
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