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Accordingly the administration of loperamide produced, in osteosarcoma-bearing mice, an increase in the concentrations of NO metabolites, nitrites and nitrates, extracted from paws.

However, we detected in Dicerfl/fl; cre+ mice an increase in apoptosis in the retina.

TP-10 treatment of the R6/2 mice resulted in statistically significantly higher levels of BDNF (20.1±0.3) compared to vehicle treated R6/2 mice, an increase of 40% (Figure 9F, 9H).

Indeed, our results showed in garlic-fed mice an increase of Gata-1 mRNA peaking at week 6 (5-fold, p<0.05) and remaining high at week 15 (1.9-fold, p<0.05) (Table 1 and Fig. 3B).

In soleus muscle, a muscle rich in type I and type IIa fibers, we found in transgenic mice an increase in the expression of MyHCI (+191%; p<0.05) associated with a reduction of type IIa (−44%; p<0.05) (Figure 6B).

Using these transgenic mice, an increase of SVZ cell proliferation after cerebral ischemia could be followed with OI.

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For example, when kidneys that do not produce interferon γ are transplanted into wild-type mice, an increased early graft necrosis is observed that can be treated with interferon γ.

In 3-week-old K5-β1 mice an increasing number of β1 integrin-positive keratinocytes was observed in lacZ-positive areas.

As expected, we observed in G93A mice an increased NF-κB activation, that is prevented in double transgenic mice (figure 4A and 4B).

In mice, an increased endosteal bone formation has been found in long-term high dose studies of PGE1 analogues (misoprostol) [ 10].

Compared to PLTPwt/wt→LDLR−/− mice, huPLTPtg/wt→LDLR−/− mice have an increase of 128% in atherosclerotic lesion area, while huPLTPtg/tg→LDLR−/− mice have an increase of 348% in atherosclerotic lesion area.

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