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Doing this increases klotho levels in mice (an effect also seen in KL-VS-positive people).
The results, published in the journal Learning and Memory, showed that the drugged animals' brains also contained far more new neurons in brain areas central to learning and memory than the brains of the control mice, an effect found by microscopic examination.
In vivo, strontium ranelate promoted bone formation and reduced bone resorption in intact mice, an effect which resulted in increased vertebral bone mass.
These observations are consistent with the observed role of intracellular XOR in promoting 3 T3-L1 differentiation and adipogenesis in vivo in mice, an effect that was mediated in part by regulation of PPARγ activity[146].
The decrease in disease severity was not due to a switch from Th1 to Th2 predominance in rJ.MY135Q-infected mice, an effect on CD8 T-cell function, or differential expression of tumor necrosis factor-α by JHMV-specific CD4 T cells.
In contrast, Akt2ko mice weighed less than wild-type mice, an effect explained mainly by a decrease in body fat.
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Therefore, in the long term and in a static situation (such as in the adult mouse) an effect of ctsk deficiency may not be observed since its function may be compensated by the upregulation of other proteases.
In the mouse, an effect of ART, from imprinting maintenance to physiological homeostasis to behaviour, has generally been found.
Oddly, ectopic expression of the hedgehog pathway's transcriptional effector GLI in developing mice produced an effect similar to loss of Ihh (216).
Addition-ally, the 4xTg mice exhibit increased insoluble SNCA, increased phosphorylated SNCA, and accelerated deposition of Lewy body inclusions compared with single-transgenic SNCA mice, suggesting an effect of Aβ and tau on SNCA pathology.
Compared with control mice, an anorexic effect of LPS was observed earlier in ob/ob mice: a reduction in food intake was noted at 8 hours and lasted until 3 days after injection (Fig. 4A).
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