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Most other melanoma-targeting agents display similar characteristic uptake in the eyes and the skin of C57BL/6 mice, a unique feature of this family of compounds [27, 28, 39].

Furthermore, tumor challenging experiments demonstrated that rLaSota/IL2 invoked mice a unique capacity to remember a pathogen through the generation of memory T cells, which protect the host in the event of reinfection and form adaptive immune system.

To address this issue, we investigated SWH in the long-lived transgenic αMUPA mice, a unique genetic model of extended lifespan.

Although fractalkine was present in salivary glands of both NOD and control mice, a unique fragment of the protein was observed in NOD mice.

In an attempt to answer this question, we explored skin wound healing in the long-lived transgenic αMUPA mice, a unique model of genetically extended life span.

This specific effect on the lung macrophage subset makes IL-3/GM-CSF knock-in mice a unique model to study the involvement of the immune system in human lung pathologies.

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The physiological roles of the Akt signalling pathway have been studied using knockout mouse models (Dummler and Hemmings, 2007); however, the PDK1K465E/K465E PH domain knock-in mice represent a unique mouse model in which Akt isoform activity is not ablated, but only moderately reduced.

Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity.

SR/CR mice are a unique colony of cancer-resistant mice derived from a single male BALB/c mouse that unexpectedly survived challenges with the extremely aggressive mouse cancer cell line S180 at doses up to several million times greater than the lethal dose for WT mice [ 1- 3].

We recently produced a line of knock-in mouse expressing a unique human-mouse chimeric PrP (Ki-ChM mouse), which has mouse-specific residues practically only at the C-terminal part after posttranslational modification, and here we attempted transmission of various human prions to assess the susceptibility profile of the mouse.

Implications and future directions These data indicate that, among the different transgenic mouse models that are used to elucidate the multiple mechanisms underlying human male infertility, SC Cx43KO mice provide a unique model for identifying candidate genes in germ cells.

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