Our microarray analysis indicates that the expression of Tfrc was not significantly changed in the duodenum of Hfe−/− mice, a result that agrees with a previous report [19].
These data suggest that early expansion of virus is amplified in sensitized mice, a result that is consistent with the increased APC migration to the LN and enhanced IL-10 expression.
We presented here our findings that a single nucleotide difference in M847 of the Gn gene of ZH501 substantially affected virulence in mice, a result that further supports the notion that RVFV virulence is under polygenic control [13].
We previously reported that recruitment of inflammatory cells characterized the lung phenotype of Hoxa5−/− mice, a result not reproduced in the current analysis (Mandeville et al., 2006).
Administration of DMPP or nicotine did not cause any hepatocellular injury in sham-operated mice, a result which correlates with negligible plasma ALT levels.
Similarly, a PLA signal was virtually absent in cortex from wild-type mice, a result that was also obtained when evaluating the PLA signal in rats, in which fluorescence was dramatically enhanced in striatal slices (supplementary material Fig. S2).
