Sentence examples for methylation in controls from inspiring English sources

These plots visually demonstrate the distribution of methylated and unmethylated probes, whereby a large fraction of the variably methylated sites have very low levels of methylation in controls and become aberrantly hypermethylated in tumors (Additional file 1: Figure S1A).

In combination with graphs for enrichment score calculations, it can be inferred whether higher methylation in controls or cases contributed most to the enrichment of the gene set.

The threshold for abnormal global hypomethylation (AGH) was calculated as the mean percentage of global methylation in controls minus two times the standard deviation.

For SCMH1 (5 CpGs), the CpG sites more distant from the TSS exhibited overall higher DNA methylation in controls and larger differences in DNA methylation between cases and controls (Additional file 2: Figure S6).

A choice of αC = 0.05 and αT = 0.25 seemed biologically reasonable to us in order to capture probes that exhibit consistently low levels of methylation in controls while presenting at least some sufficiently high level of methylation signal in tumors.

The first step of the filtering process was based on identifying a pattern where the median M-value of the different groups (matUPD7, controls, and patUPD7) would differ in the way that would be expected for an imprinted locus, i.e., methylation in controls is midway and matUPD7s and patUPD7 diverge in opposite directions.

After BRCA1 knockdown, the pyrosequencing quantitative analysis of XIST CpGs showed demethylation (88% average methylation in control siRNA vs 67% in BRCA1 siRNA) (Figure S1B).

Interestingly, we observed low-level methylation in control samples for 17 DMRs.

We illustrate the regulatory role of DNA methylation in controlling gene expression and maintaining genome transcription stability.

Those genes with values 2 fold above the median level (higher methylation) and 2 fold below the median level (lower methylation) in control are highlighted.

The observation of interchangeable effects of 5-AC and TSA indicates a mutually reinforcing relationship between histone acetylation and DNA methylation in control of cellular processes.