Sentence examples for methylation in controlling from inspiring English sources
We illustrate the regulatory role of DNA methylation in controlling gene expression and maintaining genome transcription stability.
Interestingly, a recent study also supported a role for DNA methylation in controlling mutually exclusive exons underlining the validity of our results [ 26].
This technique facilitates a number of research findings recently which includes the following: the role of RNA methylation in controlling the circadian clock [ 8], addiction [ 9], and stem cell [ 10], and [ 2, 3, 5, 6, 8– 16].
This study establishes a single-base resolution DNA methylation profile of chicken lung and suggests a regulatory role of DNA methylation in controlling gene expression and maintaining genome transcription stability.
The direct role of DNA methylation in controlling placental global gene expression levels was examined by comparing our DNA methylation data with published gene expression data for placenta tissue of the same gestational age.
Here, we comprehensively examined and compared the distribution of CpG sites within ten model eukaryotic species and linked the observed patterns to the role of DNA methylation in controlling gene transcription.
18, 35– 38 Here, we provide evidence in our model system that promoter methylation is pivotal in controlling CCNA1 expression.
These plots visually demonstrate the distribution of methylated and unmethylated probes, whereby a large fraction of the variably methylated sites have very low levels of methylation in controls and become aberrantly hypermethylated in tumors (Additional file 1: Figure S1A).
We employed a marker selection strategy that emphasized sensitivity by requiring consistency of methylation across tumors, while achieving specificity by excluding markers with methylation in control leukocyte or serum DNA.
After BRCA1 knockdown, the pyrosequencing quantitative analysis of XIST CpGs showed demethylation (88% average methylation in control siRNA vs 67% in BRCA1 siRNA) (Figure S1B).
Interestingly, we observed low-level methylation in control samples for 17 DMRs.
