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However, the paucity of methodologically sound trials prevents definitive interpretation and may obscure risks.
The lack of coherent research, and need for methodologically sound trials provides the basis for this proposed trial.
Due to a lack of methodologically sound trials, this statement is associated with a high level of uncertainty.
As a consequence, the outcomes gathered from rigorous and methodologically sound trials may not be generalizable to users within the community.
Interviews followed a semi-structured format built upon the results of the survey and were focused on participants' experiences and attitudes towards conducting pediatric research and how these interacted with the appropriate design and conduct of methodologically sound trials.
8 9 10 11 Trials that have reported large effects on joint pain were often hampered by poor study quality and small sample sizes, 9 10 11 12 whereas large methodologically sound trials often found only small or no effects.
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Each of the methodologically sound controlled trials evaluated one of two intervention types: (a) an early childhood intervention, or (b) a youth development programme.
It included all the methodologically sound randomized trials of celecoxib performed of at least 4 weeks' duration and concluded by October 2007.
We performed a systematic review with network meta-analysis including data from large methodologically sound randomised trials at multiple follow-up times to determine the effect of these preparations on joint pain and on radiological progression of disease.
Several reviews have suggested the importance of designing and conducting a methodologically sound clinical trial in the investigation of CI versus IB antibiotic administration benefits in critically ill patients [29, 38 40].
A methodologically sound multicenter trial involving a large patient group would solve this issue.
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