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Larger scale, methodologically rigorous trials are needed to consolidate these findings.
While larger scale, methodologically rigorous trials from a broader research teams are needed to consolidate these preliminary findings, emerging evidence suggests ACT is effective in the treatment of children across a multitude of presenting problems.
Nevertheless, the positive efficacy of these approaches, when understood within the framework of potential serious complications of pharmacotherapy for frail elders with multiple comorbidities, polypharmacy, and a narrow therapeutic index, suggests a strong need for methodologically rigorous trials of psychotherapy in the LTC setting, especially in combination with pharmacotherapy.
Replication is needed through methodologically rigorous trials.
Therefore, the efficacy and safety of SM as an adjuvant treatment for chronic cor pulmonale heart failure remain to be determined by methodologically rigorous trials.
19 More methodologically rigorous trials of interventions that can be delivered on a broader scale to support healthy canteen policy implementation in schools are required.
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The impact of the use of a fall risk assessment tool on clinically relevant endpoints has never been investigated within a methodologically rigorous trial.
In this methodologically rigorous trial, there was no difference in outcomes between the intensivist and control group, which consisted of in-house resident coverage at night with availability by telephone of fellows and intensivists.
This study adopts a multiple-baseline method to implement a methodologically rigorous trial of an innovative intervention in which radiation therapists take an active role in providing sensory and procedural information and anxiety reduction techniques using a consultation prior to treatment planning and treatment at key time points during the patient's radiotherapy journey.
Recently, a small but methodologically-rigorous trial focused on suicidal behavior prevention [ 50] observed only nonsignificant differences in suicidal behavior between lithium and valproate.
There is evidence from methodologically rigorous controlled trials that exercise, psycho-educational interventions, and cognitive-behavioral therapy for insomnia are effective in the treatment of CRF, and a wide range of pharmacologic and nonpharmacologic interventions has shown initial promise in single-arm pilot studies with small, heterogeneous samples.
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