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If implemented, these strategies will improve the production and interpretation of the methodologically challenging and always-growing evidence for and against cancer screening.
However, case control studies are recognized to be methodologically challenging and inferences should be drawn with caution.
In order to inform public health policies, well conducted cluster randomised control trials with peer support as part of a complex or multicomponent intervention should be encouraged, but these would be methodologically challenging and expensive to conduct.
Conducting randomised controlled trials with people facing the end of life can be both ethically and methodologically challenging and therefore it is important to progress methodically through the phases of Medical Research Council (MRC) Framework for Complex Interventions [ 18, 19], examining both the acceptability and feasibility of the intervention and the associated study design [ 20].
However performance measurement is methodologically challenging and public performance reporting may give rise to unintended consequences such as patient selection by providers [ 72], data misrepresentation to improve perceived performance, and prioritization of narrow, organization-specific objectives to the detriment of wider health system goals [ 73].
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Activation studies in clinical samples can be methodologically challenging [14] [17] and one potential method for examining how plasticity is expressed in the injured brain during recovery is to first document how resting networks are altered.
This is an important but methodologically challenging area and outcomes should include service user evaluation of their experiences.
While impact evaluations could be regarded as costly and methodologically challenging (often requiring the identification of control groups that are deprived from a certain service at some point of time), the cost of impact evaluation are often small when compared to total program allocations.
Exposure assessment has always been one of most methodologically challenging aspects of environmental health science and environmental epidemiology.
Eliciting tacit knowledge can be methodologically challenging given that such knowledge is difficult to articulate and is often embedded in routine practices.
[ 5, 6] In turn, this new focus has opened up the possibility of comparing the impact of work roles on both women and men, though this continues to be methodologically challenging, partly because of gender segregation in the labour market.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com