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Their evaluation, however, is methodologically difficult and the few existing studies are controversial.
However, estimating self-pollination rate is methodologically difficult, and only a few studies have made population-wide estimates for Asclepias spp. [ 34- 36].
Recognizing that power is methodologically difficult and sensitive to investigate (Erasmus and Gilson 2008; Lehmann and Gilson 2013) we sought to gather information by asking questions on 'which actors carried the most influence in the policy process and why'.
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Since conserved gene-level changes are rather rare events, differ between individuals, and methodologically difficult to assess, pathway-level analysis detects multiple relevant gene changes in different individuals within the same phenotype (here, PD), which consists of the entire repertoire of all responsible changes eventually leading to the same phenotype: PD.
Evaluating any complex intervention is practically and methodologically difficult.
However, as outlined above, this is often conceptually unsound and methodologically difficult.
However, these approaches rely on expensive, specialized equipment for automated cell sorting, or complicated and methodologically difficult manipulation tools.
The significance of pedagogy in teaching assistant #1's sections presents a very important observation that is intuitively obvious and methodologically difficult to demonstrate.
Unfortunately, pollen limitation is methodologically difficult to estimate [ 73, 74] and probably varies spatially and temporally within a species [ 24].
Directly ascertaining utilities in critically ill patients is done infrequently and is methodologically difficult [ 12].
Although methodologically difficult, the latter can evaluate randomization methods and correctness of data, re-analyze the original data, perform additional analyses and update patient outcomes that become 'frozen' in time, and can thus overcome the limitations of abstract patient data meta-analysis [ 6].
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