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A detailed description of the adopted set-up and results from a methodological study on the detection limits for the selection of the optimal beam energy are shown; the outcomes of the research on alternative collecting substrates, which produce a lower background during the measurements, and with lower contaminations, are also discussed.

This is in accordance with previous findings in a methodological study on cadaver pelvises (Siebenrock et al. 2003).

Since this was a retrospective and methodological study on the results already available with us, it was not put up for any clearance to an ethical committee.

Lastly, for the purposes of this methodological study on imputation methods, we excluded the 351 participants of our surgical outcomes study who had truly incomplete SDS questionnaires.

Since this was a retrospective and methodological study on the isolates already available with us, it was not put up for any clearance to an ethical committee.

In order to provide a better basis for involvement of nurses in future studies of this kind we decided to carry out an additional methodological study on determinants of the low participation of nurses.

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The threshold to differentiate between low and high risk of bias studies was based on a methodological study of van Tulder et al, 31 in which they assessed the validity of the Cochrane Collaboration's tool for assessing risk of bias in trials of interventions for back pain.

To summarize the findings of methodological studies on the RAND/University of California Los Angeles (RAND/UCLA) appropriateness method, which was developed to assess if variation in the use of surgical procedures is because of overuse and/or underuse.

The identification of cohort studies for this review was conducted as part of a comprehensive search for empirical and methodological studies on research dissemination bias.

The prokinetic agents available have been reviewed [ 12], although a subsequent commentary highlighted the lack of any large methodological studies on which to base treatment recommendations [ 10].

However based on previous methodological studies of the KOOS, we expected the correlations to the SF-36 subscale Role Physical to be lower than the correlations to the subscales Physical Function and Bodily Pain [ 6, 9].

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