In order to increase the power of genome wide association studies (GWAS) to identify the biological mechanisms underlying complex disease, the field is leveraging many methodological advances on the analysis of gene expression microarray data.
In this contribution, we have discussed methodological advances for activity prediction on the basis of SARMs, which systematically account for structural/analog relationships in compound sets of any source, organize structurally related compound series, and yield virtual candidate compounds.
Expanding beyond this narrow view, we focus this review on pertinent questions and novel methodological advances for the multi-scale brain.
The experiment is also important because it introduces a methodological advance over the previous ones.
However, these goals will require conceptual and methodological advances focusing on how best to integrate different pubertal measures within developmental studies of adolescent brain and behavioral maturation.
After a brief period of promiscuous false discovery, methodological advances based on agnostic statistical approaches have yielded hundreds of confirmed associations between genes and disease. 1 Rapid improvements in "next generation" sequencing mean that people will soon be able to carry their genome on a memory stick at an affordable cost.
Finally, methodological advances based on the physics of ice formation have enabled variable-temperature crystallographic data collection at temperatures between 300 and 100 K with modest or no use of potentially conformation-perturbing cryoprotectants (Warkentin et al., 2012; Warkentin and Thorne, 2009).
In a methodological advance, 2R ohnologs were identified using detailed phylogenetic trees on the basis of a tree-merging algorithm implemented in the TreeFam database.
Not only has a methodological advance been demonstrated, but also the results hold possible medical significance.
