Kenneth Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience Randomised controlled trials, when appropriately designed, conducted, and reported, represent the gold standard in evaluating healthcare interventions.
The methodological quality of the evidence on the rK39 ICT and the latex agglutination test was acceptable, although we had concerns about the risk of bias in some studies (see below).
This review was conducted to identify and systematically summarize existing evidence on outcomes and methodological quality of simulation-based skills training for cardiac surgery trainees.
What are the methodological challenges of evaluating and synthesising evidence on CM?
What are the methodological challenges of evaluating and synthesising evidence on CM? Standard systematic review procedures were followed (Fig. 1).
Some examples of methodological topic areas include: Priority setting for health R&D – methodologies for defining needs (including evidence on burden of disease, evidence on severity of disease, product gaps, demand/market size projections, stakeholder values, etc).
All these methodological shortcomings hamper interpretation of the currently available evidence on outcome of adjuvant (H IPEC.
Evidence on the subject of comparability of methodological approaches for measurement of adherence to AIs is scarce.
Methodological alternatives to RCTs have been proposed to obtain robust evidence on AD and dementia prevention [ 11, 53].
In the absence of empirical evidence on the extent to which a particular methodological flaw influences the results, the assessment of study quality necessarily entails judgment.
