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The results of the critical appraisal according to the most important methodological quality dimensions of each article are shown in (see Additional file 1).
Sensitivity and subgroup analyses according to the main methodological quality dimensions [ 7] and a number of clinical criteria were also performed (see fig 2 and 3).
Data were abstracted on patient characteristics, type of tumor, treatment details and the major methodological quality dimensions [ 4, 7] (see Additional file 1).
Although comprehensive, some issues were not addressed in this previous SR/MA: a formal quantitative synthesis (meta-analysis) was not performed according to different clinical aspects and to main methodological quality dimensions empirically linked to bias [ 7].
Despite the fact that most studies scored well on most methodological quality dimensions, model validation still formed a weak spot: in some studies there was no report on how performance measures were obtained and in others there was no independent validation set used.
Thus, it appears that the effect of EPO is a rather robust despite heterogeneity noted in the meta-analysis Sensitivity and subgroup analyses according to clinical and methodological quality dimensions (Fig 2 and 3) showed consistency in the results, favoring the use of EPO.
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The quality appraisal instrument devised by Philips et al. [ 24] include dimensions of methodological quality corresponding to rationales for structure, structural assumptions, disease states/pathways, cycle length, and internal consistency.
We separately assessed the potential for systematic error within individual studies using the Cochrane risk of bias tool [ 30] and the following dimensions of methodological quality: (1) generation of allocation sequence; (2) allocation concealment; (3) blinding (participant and researchers); (4) blinding of outcome assessors; (5) completeness of outcome data; (6) selective outcome reporting.
Regarding the quality dimension of " applicability" (dimension F), all appraisal instruments provide a standard reporting format and present items of methodological quality and transparency.
The overall methodological quality for each study was calculated using the average score of the eight dimensions.
Responsiveness is one dimension of great importance to determine when evaluating the methodological quality of a measurement.
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