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The purpose of this article is to summarize the recent history of methodological quality considerations, synthesize the recommendations found in the SCED literature, and provide recommendations to researchers designing SCEDs with regard to essential and aspirational standards for methodological quality.
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KW assessed reports for eligibility against previously agreed criteria and for methodological quality without consideration of their results.
Nevertheless, our assessment of methodological quality highlights some considerations for improving the design and analysis of future studies.
Randomized controlled studies (RCT) were assessed for methodological quality, taking into consideration the specific diagnostic and severity evaluation tools used, and a meta-analysis on the efficacy of SSRIs compared placebo was undertaken.
Rigorous methodological quality includes, among other considerations, data quality and appropriate risk adjustment [ 15, 48].
Methodological quality is an important consideration when combining trials in a meta-analysis.
Given the clinical heterogeneity and insufficient data for statistical pooling, trials were described in a narrative way, taking into consideration methodological quality scores.
Studies were not excluded from consideration based on the quality appraisal in keeping with the methodology; 14 16 however, methodological quality of included papers is reported so that the review findings can be read with that context in mind.
Finally, R-AMSTAR scores identified that La Touche et al. (2008) [ 6] and Pereira et al. (2012) [ 8] needed to improve consideration of the methodological quality of the primary studies when formulating conclusions.
Methodological quality of included studies varied considerably.
The methodological quality of studies ranged from fair to good, with study attrition, and its subsequent consideration in the analysis process, being a primary methodological flaw.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com