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Independent raters coded participant, design and methodological characteristics and intervention content.

Methodological characteristics and quality are presented in Table 1.

We described the methodological characteristics and rigour of child-relevant reviews in the CDSR.

Content analysis was used because of its methodological characteristics and reliable measures to achieve trustworthiness.

From included articles, data were extracted on the methodological characteristics and results of the publications.

Subsequently, the two reviewers independently analyzed the methodological characteristics and results of the studies, using the protocol as described below.

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We extracted a number of variables on study design and methodological characteristics, patient and intervention characteristics, and outcomes from all eligible studies (see appendix).

Each eligible trial was independently reviewed by two of us to abstract data on methodological characteristics, OMT and control treatments, and low back pain outcomes.

We investigated potential sources of heterogeneity using subgroup analyses based on methodological characteristics, quality and patient characteristics.

To determine the prevalence of trial registration in randomized controlled trials (RCTs) published in 2010 (PUBMED/LILACS) from Latin America and the Caribbean's (LAC) and to compare methodological characteristics between registered and nonregistered RCTs.

Data were recorded using a standardised data collection form to record study design and methodological characteristics, patient characteristics, interventions, and outcomes, including the relative risks and 95% confidence intervals.

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