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Previous studies had methodological flaws, and their results were contradictory.
Because earlier studies have methodological flaws and cannot provide recommendations, more research is needed.
The professional society for urologists and some cancer experts have challenged the conclusions, saying they are based on studies that have methodological flaws and that only followed participants for a decade, not enough time, they claim, for a final judgment.
Importantly, most trials have important methodological flaws and have used inconsistent methods and therapeutic endpoints [29].
They have serious conceptual and methodological flaws, and do not take into account the latest knowledge in environmental sciences.
Despite the promise of measuring key skills, the reality is that personality tests have serious methodological flaws and lack the statistical reliability to predict performance among prospective employees.
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The overall quality of the information about menopause (from professional and non-professional sources) is poor and it has clear methodological flaws, contradictions and conflicts of interests (economic and professional) [ 6].
From a wide variety of methodological flaws, sampling bias, and experimental design constraints inherent to 38 of the 40 field studies we assessed, we demonstrate that there is presently unreliable and inconclusive evidence for dingoes' role as a biodiversity regulator.
Finally, the evidence and recommendations were synthesized in a draft of the target guideline, and the results and possible methodological flaws of the included source-guidelines, and the re-assessed studies, were discussed.
The findings from this review are subject to substantial and unexplained heterogeneity, and the impact of publication bias and methodological flaws such as blinding to study allocation could not be ruled out.
The evidence base for the benefit or lack of benefit of corticosteroids in dengue is limited; previous studies have been small, with methodological flaws, less stringent randomisation and unclear allocation concealment, and were performed a long time ago.
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