LV wall mass was found unchanged as assessed by echocardiography, possibly due to methodological limitations and limited imaging quality in some patients.
Based on the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system, we have classified the quality of the evidence as 'moderate' for depression and 'low' for anxiety, due to the methodological limitations and the limited number of trials.
Thus, high risk of bias should be considered when interpreting the results, due to the above methodological limitations and the overall limited information (four studies) available.
In addition, the few studies published have important methodological limitations and are very heterogeneous, which limits the available evidence about the cost effectiveness of LBP interventions [ 17, 18].
In such we feel that such items do help draw attention of the readers to potential methodological limitations, and thus reduce assumptions that the methodology was sound.
Nevertheless, understanding the inherent methodological limitations of a systematic review should lead to minimisation of these methodological limitations and optimisation of the remaining review methodology, which is the objective of this paper.
Data were limited by variability in the types of comparator groups, methodological limitations, and poor reporting of outcomes.
The chapter finishes with an outline of methodological limitations and areas for future research.
In contrast, results of aging studies on automatic semantic retrieval are often inconsistent, probably due to methodological limitations and differences.
Nearly all of these trials were characterized by methodological limitations, and all but two involved participants without clinically significant depression at the start of the study.
But the European Medicines Agency said on Friday that Dr. Butler's study had "a number of methodological limitations and potential sources of bias".
