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This study reflects on methodological challenges encountered in two IPD meta-analyses on self-management interventions in patients with heart failure or chronic obstructive pulmonary disease.
We also discuss its underlying architectural design, which revolves around a clinical event monitor and a rules engine, and the methodological challenges encountered in designing this application.
The current paper outlines the study protocol, explains the rationale for the study design and selection of outcome measures, and documents several methodological challenges encountered.
The study describes the methodological challenges encountered in an observational study estimating the effectiveness of colonoscopy in reducing colorectal cancer (CRC) incidence and mortality.
The present paper provides a description of the cohorts included in the project, focuses on the post harmonization procedures to merge these cross-national data and describes the methodological challenges encountered in the process of harmonization.
In this paper we discuss the methodological and practical challenges faced; of particular note are the methods used in our synthesis, the additional steps that we found useful in clarifying the process, and the key methodological challenges encountered in implementing the meta-ethnographic approach.
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This complex pathophysiology adds to the methodological challenges commonly encountered when studying genetic associations.
Future studies should also improve on the methodological challenges we encountered in our study.
We discuss the scope for applying realist evaluation and the methodological challenges we encountered in developing this protocol.
This involves methodological challenges not encountered to the same extent by researchers working on the tobacco industry, who have access to internal industry documents.
The DCOG LATER-VEVO study is the first nationwide childhood cancer survivor study in the Netherlands and during the study period several methodological challenges were encountered.
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