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Such research will only be effective if we can overcome the methodological challenges discussed here.
It must be noted that some of the methodological challenges discussed here may be specific to Finnish data as hospital discharge registers vary by country.
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Methodological challenges are discussed in regard to sampling issues, the management of data, data analysis and validity checks.
Empirical results as well as methodological challenges are discussed.
Key methodological challenges are discussed in relation to: translating multi-component theoretical constructs into simple questions; developing and choosing appropriate outcome measures; conducting multiple-stakeholder assessments; instrument and question framing; and more general issues for instrument development in practice contexts.
We advocate the urgent need to expand efforts directed at the methodological challenges and discuss the direction of applications in this field.
Here, we account for the trial design, address methodological challenges, and discuss the estimation of sample size.
We present a study design that copes with these methodological challenges and discuss the methodological implications of our choices, using a quality assessment tool for diagnostic accuracy studies (QUADAS-2).
A number of prior analyses have discussed methodological challenges in describing the natural history of HPV disease [ 27, 29- 31], and several explicit choices concerning alternate data sources and study designs were made in the present review.
We discuss methodological challenges to studying RRA and offer suggestions for future research.
To discuss methodological challenges and potential solutions, the Food and Drug Administration and the National Cancer Institute convened a two-day public meeting in 2014.
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CEO of Professional Science Editing for Scientists @ prosciediting.com