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Perhaps most striking was the demonstration that feeding rodents exclusively during the rest (light) period, when they normally sleep, inverts the phase of diurnal variation in the clock gene's expression in metabolic tissues, including the liver and fat [30], [31].
Obese subjects show activation of ER stress pathways in metabolic tissues including adipose tissue, liver, and pancreas (64, 65).
We find that XY and XXY mice differ in several measures of body composition and metabolic tissues including body weight, fat mass, lean mass, and metabolic tissue weights.
PPARα is abundant in highly active metabolic tissues including the liver, kidney, heart, muscle, brown adipose and macrophages, whereas PPARγ is predominantly found in adipose tissue, macrophages and large intestine.
To further define the basis for differences in body weight and composition among genotypes, we measured the weights of key metabolic tissues, including representative visceral and subcutaneous fat pads (gonadal and inguinal fat depots, respectively), liver, spleen, and kidney.
Intriguingly, however, urocortins are also present at high levels in peripheral metabolic tissues, including skeletal muscle [ 11, 12], implying that these 'stress regulators' have local peripheral as well as central metabolic actions.
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VEGFs mediate a wide range of responses in different tissues including metabolic homoeostasis, cell proliferation, migration and tubulogenesis.
LEPROTL1, a gene widely expressed in human tissues, including metabolic tissues such as muscle and liver [ 83, 84, 86], has an influence on growth, plasma insulin-like growth factor-1 levels, hepatic sensitivity to growth hormone, and cell-surface growth hormone or leptin receptor expression and leptin signaling [ 87, 88].
Estrogen is known to exert its effects mainly through the estrogen receptor (ER), and estrogen/ER signaling is a well-known regulator of metabolic and glucose-sensing tissues, including pancreatic β cells, liver, adipocyte, and skeletal muscle (Faulds et al. 2012).
Elevated plasma insulin levels can lead to numerous metabolic and pathological derangements in various tissues, including the heart (27).
GH regulates several metabolic processes in cells and differentiated tissues, including cell growth and proliferation; pituitary, prostate, and adrenal gland sizes; and the size of accessory reproductive organs (Cohen and Radovick 2002; Mogi et al. 2005; Stoker et al. 2002), which may explain the diverse effects noted in previous studies.
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