The other seven up-regulated proteins in the DsRNA- Xoo3 mutant were assigned to various metabolic functions, including glutathione metabolism, fatty acid metabolism, lipopolysaccharide, and sucrose metabolism.
This reconstruction also implies that the versions of the β-GF associated with major metabolic functions, including respiratory metabolism, radiated from the ancestral RNA-binding versions.
Of particular interest is the significant (p<0.05) but modest elevation of AEA in subjects with the FAAH 385 mutant A alleles (Figure 1), since AEA activates the CB1 receptor and has the potential to stimulate appetite and feeding behavior as well as modulate several metabolic functions including fatty acid metabolism and contributes to diet-induced obesity [12], [16].
It is associated with specialized metabolic functions including stationary phase metabolism, the stringent response, protein secretion, and cellular differentiation, playing a special role in the assembly of multienzyme complexes that synthesize secondary metabolites containing peptide or polyketide bonds [ 34].
Drosophila Gpdh has two well-characterized metabolic functions, including bridging glycolysis and triglyceride metabolism and serving in the glycerol-3-phosphate shuttle to regenerate NAD+ from NADH in mitochondria [37].
Metabolic functions including C-compound and carbohydrate metabolism (Δ wc-1 P-value = 2.17e-08; Δ wc-2 P value = 5.00e-09) were strongly down-regulated in these strains individually as were genes contributing to energy supply (Δ wc-1 P-value = 1.89e-07; Δ wc-2 P value = 7.54e-08).
Stress-responsive genes with metabolic functions included SC4MOL, CHST2, amy2a, ACAD, dgat2l, dcxr, and fuca1.
The embryos had fewer stem cells than those of pregnant rats fed a normal diet and, after birth, had differences in organ size, weight, growth, and metabolic function, including blood pressure.
Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function.
7 LCR rats have impaired metabolic function, including obesity, insulin resistance, and dyslipidemia.
Adipose tissue is now recognised as a major endocrine organ that secretes signalling molecules playing a central role in inflammation, weight regulation and metabolic function including cytokines (Trayhurn, 2005).
