Sentence examples for metabolic pathways regulated from inspiring English sources

The reason would be that, since we employed cerulenin during mutant screening step, we may have selected those individuals presenting mutations on genes present in the same metabolic pathways regulated in the studies above mentioned.

Finally, by thoroughly investigating the metabolic pathways regulated by truncated cytoMet, human immortalized hepatocytes maintaining features of differentiated liver cells could be produced and used in toxicology studies.

These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores.

We then used the resulting framework to address the question whether metabolic pathways regulated by both metabolic interactions and through gene expression, come close to the ideal control structures designed in control engineering.

To investigate the metabolic effects of reducing cortisol action in individuals with Type 2 diabetes we have tested the effects of acutely reducing cortisol action on the key metabolic pathways regulated by insulin.

Although the toxicologic effects of activating NR1I2 are not completely understood, the metabolic pathways regulated by NR1I2 implicate it as a potential target for disrupting bile acid and steroid homeostasis (Zhai et al. 2007).

The mTOR complex 1 is also involved in the regulation of several metabolic pathways, regulating the expression of genes encoding different steps of glycolysis and the pentose phosphate pathway, as well as critical enzymes in the de novo biosynthesis of lipids [ 22].

ChREBP is thus at the crossroads of the different glucose metabolic pathways regulating beta cell differentiation from pancreatic progenitors.

More specifically, a number of vitamins and micronutrients are substrates and/or cofactors in the metabolic pathways regulating DNA synthesis and/or repair and gene expression [ 23].

This analysis indicates that metabolic pathways regulating fatty acid, phospholipid, and cholesterol biosynthesis were coordinately decreased after deletion of Stat3 in type II cells, supporting an important role of STAT3 in regulating lipids biosynthesis in the lung.

Mouse mutant models have been extensively used to identify candidate genes regulating complex traits, such as growth and body fat [ 1- 4], providing insight into the metabolic pathways regulating these traits.