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Second, the larger the amplitude of an excitatory membrane potential trajectory, the higher the temporal precision of the evoked spike response.

Our data suggest that at the threshold level, STP in layer V neocortical pyramidal neurons is quite sensitive to the time course of the membrane potential trajectory induced by different EPSC kinetics.

Below, membrane potential trajectory of the RTN cell shown at high magnification, featuring spontaneously rhythmic (stars) and light-evoked (blue bars) bursts of action potentials.

(F ) Top row, trace of the membrane potential trajectory of the biocytin-labeled cell in E showing spontaneous burst discharges of action potentials (indicated by *) at pH7.4 (7.4); bottom row, same trace at pH7.2 (7.2).

Addition of noise to a single E or I cell increases variability in its membrane potential trajectory approximating that seen in vivo (Domnisoru et al., 2013; Pastoll et al., 2013; Schmidt-Hieber and Häusser, 2013).

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Fig. 4B shows example membrane potential trajectories for different input frequency values (F = 10, 30, 50 Hz).

By contrast, peaked post-spike membrane potential trajectories will enhance the ability of a cell to lock its discharge to oscillatory input.

RBC membrane potential reacted with a sinusoidal trajectory, tapering in amplitude at the higher frequencies (Figure 3B, second trace from top).

a The blow-up of the temporal trajectory of for V (the average membrane potential) of two clusters, during a fraction of the period, where the two clusters reach the peak potential successively.

A limit cycle is obtained when there is no threshold operation applied to the membrane potential, so that the three-dimensional dynamical system of the membrane potential is attracted to its stable trajectory (Appendix S1, Eq. 5).

The two types of spiking trajectories depends on whether the adaptation current immediately after spiking is strong enough to make the membrane potential decrease slowly before starting to increase in preparation for the next spike.

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