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Exact(8)
Future work will focus on discerning if this association is attributable to anesthetic exacerbation of membrane potential dissipation caused by selective impairment of complex I subunits that contribute to proton gradient flux.
Sequential administration of both cytostatic agents led to increased intracellular platinum accumulation, glutathione level depletion and mitochondrial membrane potential dissipation.
The decrease in the green fluorescence is a marker of mitochondrial membrane potential dissipation and is measured as percentage of cells shifting towards the left.
(9) Although the results presented here support binding of nisin to lipid II, they do not establish whether lipid II is important for nisin-dependent membrane potential dissipation.
It should, however, be noted that mitochondrial fragmentation without membrane potential dissipation does not induce Parkin-dependent mitochondrial turnover, suggesting that mitochondrial fission is necessary but not sufficient for mitophagy.
Oxidative stress induced under galactose conditions leads to mitochondrial damage in the form of mitochondrial inner membrane potential dissipation, ATP drop and necrotic cell death, together with increased levels of oxidative modifications in cyclophilin D protein.
Similar(52)
Although Zfra may block cytochrome c release, overexpressed Zfra causes mitochondrial membrane potential (MMP) dissipation [ 29].
This leads to increased reactive oxygen species (ROS) production, mitochondrial membrane potential (∆Ψm) dissipation, degradation of the mitochondrial membrane and the release of cytochrome c.
It also could improve SGC-7901 cell apoptosis, mitochondrial membrane potential assay indicated that the dissipation of MMP might participate in apoptosis induced by title compound.
Accordingly, mitochondria uncoupled by 50 nM FCCP at the beginning of the experiment could not be activated by the following Ca2+ titration, owing to the dissipation of membrane potential (Fig. 1G).
The extensive dissipation of membrane potential likely reflects damage of the cell membrane.
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